Ethyl 2-methoxy-5-sulfamoylbenzoate

Ethyl 2-methoxy-5-sulfamoylbenzoate - Names and Identifiers

Name	Ethyl 2-methoxy-5-sulfamoylbenzoate
Synonyms	Sulpiride IMpurity C Sulpiride EP Impurity C Sulpiride Impurity C(EP) Ethyl 5-sulphamoyl-o-anisate Ethyl 2-methoxy-5-sulfamoylbenzoate 2-Methoxy-5-sulfamoyl ethyl benzoate Ethyl 2-methoxy-5-(sulfamoylmethyl)benzoate 2-Methoxy-5-sulfamoylbenzoic acid ethyl ester 2-METHOXYL-5-METHYLSULFONYLBENZOIC ACID METHYL ESTER
CAS	33045-53-3
EINECS	251-359-7
InChI	InChI=1/C10H13NO5S/c1-3-16-10(12)8-6-7(17(11,13)14)4-5-9(8)15-2/h4-6H,3H2,1-2H3,(H2,11,13,14)

Ethyl 2-methoxy-5-sulfamoylbenzoate - Physico-chemical Properties

Molecular Formula	C10H13NO5S
Molar Mass	259.28
Density	1.317±0.06 g/cm3(Predicted)
Melting Point	148-151 °C
Boling Point	446.5±55.0 °C(Predicted)
Flash Point	223.8°C
Solubility	DMSO (Sparingly), Methanol (Slightly)
Vapor Presure	3.63E-08mmHg at 25°C
Appearance	Solid
Color	White to Off-White
pKa	9.95±0.60(Predicted)
Storage Condition	Refrigerator
Refractive Index	1.535
Use	Used as a drug sulpiride Intermediate

Ethyl 2-methoxy-5-sulfamoylbenzoate - Reference Information

use

2-methoxy-5-sulfonamide ethyl benzoate is an important intermediate of antipsychotic sulpiride and levosulpiride, sulpiride (sulpiride), the chemical name is N-[(1-ethyl-2-pyrrolidinyl) methyl] -2-methoxy-5-(sulfamoyl) benzamide; it was synthesized by the French in 1967 because of its It has the effect of treating mental disorders and has few adverse reactions. It has been used clinically for many years at home and abroad.

preparation

300g tetrahydrofuran, 0.25 ethyl mol2-methoxy -5-chlorobenzoate, 1.8g cuprous bromide (0.0125mol),25.7g(0.25mol) sodium aminosulfonate will be added to a 1000ml reaction bottle equipped with a reflux device, and the temperature will be increased to 65 ℃, at this temperature for 12 hours, the heat preservation is finished, 2 grams of activated carbon is added to the reaction solution and filtered while hot, the filtrate is concentrated to dry under reduced pressure, and dried under vacuum at 60 ℃ to obtain 57.9g(0.236mol) of 2-methoxy -5-sulfonamide ethyl benzoate white crystal powder with 94.5% yield and 99.51% content (HPLC). Among them, HPLC detection conditions: mobile phase: 700 ml of water; Methanol 200 ml. Detection wavelength: 240nm, flow rate 1.0 ml/min, sample 0.01g, diluted to 25 ml with mobile phase, injection volume 5 μl.

Last Update：2024-04-10 22:29:15